CD284 (TLR4) Antibody, anti-human, Vio® B515, REAdye_lease™，130-132-857，美天旎

Clone REAL1458 is an antibody fragment derived from the full CD284 (TLR4) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.

Clone REAL1458 recognizes the human CD284 (TLR4) antigen, a type I transmembrane signaling receptor also known as Toll-like receptor 4. Toll-like receptors are a family of pattern recognition receptors detecting the presence and characteristics of an infection and induce appropriately tailored innate and adaptive immune responses. TLR4 associates with its co-receptor MD-2. Together with the lipopolysaccharide (LPS)-binding protein (LBP) and CD14, this complex is responsible for signaling upon LPS recognition. CD284 (TLR4) is expressed on monocytes and myeloid dendritic cells. Low levels are expressed on B cells and granulocytes in human peripheral blood. HTA125 is able to block LPS-induced signaling and recognizes predominantly human TLR4 associated with MD-2.

For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Toll-like receptor 4, hToll, TLR-4

Technical specifications