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General description
Cell-permeable phosphatidylinositol 3-kinase (PI 3-kinase, PI3K) activator.
740 Y-P is a cell-permeable phosphatidylinositol 3-kinase (PI 3-kinase, PI3K) activator composed of the Drosophila antennapedia-derived membrane-permeant 16-mer sequence RQIKIWFQNRRMKWKK followed by a phosphotyrosine-containing, PDGFR-derived sequence SDGGY(P)MDMS that targets SH2 domains of PI3K p85 regulatory subunit. When applied to serum-starved C2 cells at 50 µg/mL, 740 Y-P is more effective than 10% FCS, 5 ng/mL bFGF or 10 ng/mL EGF in stimulating cell proliferation (% of cells in S-phase post 48h stimulation = 48.3, 42.5, 35.7 and 32.8, respectively). 740 Y-P-induced mitogenic response is blocked by wortmannin or rapamycin, but not MEK inhibitor PD98058.
Disclaimer
Hygroscopic Store with desiccant
| Quality Level | 100 |
| assay | ≥95% (HPLC) |
| form | (Powder or Lyophilized powder or film) |
| storage condition | desiccated |
| color | white to off-white |
| storage temp. | -10 to -25°C |
| 长度(mm) | |
| 宽度(mm) | |
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| 重量(kg) |
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¥ 1683.78
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¥ 1956.41
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¥ 8520.40
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¥ 9737.84
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¥ 238.17
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¥ 1653.62
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¥ 14407.09
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¥ 1568.60
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¥ 2307.00
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¥ 4476.05
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