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- 规格参数
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Biochem/physiol Actions
Ophiobolin A is a fungal metabolite, toxic to many crops and found to have antimicrobial and anticancer activity. Ophiobolin A is a calmodulin antagonist and inhibitor of big conductance Ca2+-activated K+ channel (BKCa) activity. Its anticancer activity may involve inhibition of multiple oncogenic signaling pathways including PI3K/mTOR, Ras/Raf/ERK and CDK/RB. One study suggested the possibility of pyrrolylation of lysine residues on its intracellular target protein(s) as a mechanism of action on various targets.
Ophiobolin A is a fungal metabolite; calmodulin antagonist with anticancer activity.
Other Notes
Light and air sensitive.
| biological source | (from Biopolaris leersia fungal metabolite) |
| Quality Level | 100 |
| assay | ≥95% (HPLC) |
| form | powder |
| storage condition | protect from light |
| color | white to beige |
| storage temp. | −20°C |
| SMILES string | [H]C(/C1=C/C[C@]([C@]2(O[C@@H](C=C(C)C)C[C@@H]2C)CC3)([H])[C@@]3(C)C[C@@]([C@](C)(O)C4)([H])[C@]1([H])C4=O)=O |
| InChI | 1S/C25H36O4/c1-15(2)10-18-11-16(3)25(29-18)9-8-23(4)12-19-22(20(27)13-24(19,5)28)17(14-26)6-7-21(23)25/h6,10,14,16,18-19,21-22,28H,7-9,11-13H2,1-5H3/b17-6-/t16-,18-,19-,21+,22+,23+,24+,25-/m0/s1 |
| InChI key | MWYYLZRWWNBROW-BDZRSQQBSA-N |
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¥ 20380.83
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¥ 1476.00
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¥ 1564.00
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¥ 30616.15
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