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General description
Ester precursor of the STING(A230/I230)-selective agonist BDW568-OH with no activity toward STING(G230).
BDW568 is an ester precursor of the STING(A230/I230)-selective agonist BDW568-OH with no activity toward STING(G230). Upon entering cells, BDW568 is hydrolyzed by carboxylesterase 1 (CES1) to the active metabolite BDW568-OH, which in turn induces cellular type-I interferon (IFN-I) signaling (EC50 = 7.6 μM by ISRE reporter assay using THP-1 cells, 4.1 μM using STING-/- THP-1 expressing STING with H71, A230, Q293).
Disclaimer
Hygroscopic Store with dessicant
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated,protect from light |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
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¥ 2013.69
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瓶顶过滤器-500ml容量,MF75TM系列，聚苯乙烯外壳，75mmSFCA滤膜，孔径0.2um,适合瓶颈尺寸45mm，12/箱，291-4520，Nalgene，Thermofisher，赛默飞世尔¥ 2856.42
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¥ 4404.38
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¥ 2151.46
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