- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
MEPB is a modulator of the activation function-2 (AF-2) of the androgen receptor (AR), increasing AR co-repressor binding. MEPB specifically binds the BF3 pocket of the androgen receptor where it modulates binding of co-regulators to the AF2 domain. MEPB was found to rescue degeneration in a mouse model of spinal bulbar muscular atrophy, a motor neuron disease caused by toxic gain of function of the androgen receptor.
Modulator of the activation function-2 (AF-2) of the androgen receptor (AR)
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | −20°C |
| SMILES string | CC(C=C1)=CC=C1OCCN2C(SCCOC3=CC=CC=C3)=NC4=CC=CC=C42 |
| InChI | 1S/C24H24N2O2S/c1-19-11-13-21(14-12-19)27-16-15-26-23-10-6-5-9-22(23)25-24(26)29-18-17-28-20-7-3-2-4-8-20/h2-14H,15-18H2,1H3 |
| InChI key | PNCBJXVNIRRHJP-UHFFFAOYSA-N |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
询价
-
¥ 1573.49
-
¥ 3109.49
-
询价
-
询价
-
询价
-
询价
-
询价
-
询价
-
¥ 6330.00
-
询价
-
询价
-
询价
-
¥ 3319.60
-
¥ 1564.00
-
¥ 1156.91
-
¥ 2277.64
-
¥ 3404.94
-
¥ 2911.61
-
¥ 10685.48
微信小程序
7X24小时在线咨询