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Biochem/physiol Actions
Demethyleneberberine, a berberine metabolite, is a mitochondria-targeted antioxidant isolated from Cortex Phellodendri chinensis that exhibits multiple pharmacological activities including anti-microbial, anti-inflammatory, anti-diarrhea and anti-cancer. Demethyleneberberine alleviates ethanol-dependent oxidative stress by suppression of cytochrome CYP2E1 (P450 2E1), hypoxia inducible factor α (HIF-1α) and inducible nitric oxide synthase (iNOS). It appears that demethyleneberberine attenuates non-alcoholic fatty liver disease (NAFLD) through activation of AMPK.
Mitochondrially targeted antioxidant
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | , White to very dark grey |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | [n+]21c(cc4c(c2)c(c(cc4)OC)OC)c3c(cc(c(c3)O)O)CC1 |
| InChI | 1S/C19H17NO4/c1-23-18-4-3-11-7-15-13-9-17(22)16(21)8-12(13)5-6-20(15)10-14(11)19(18)24-2/h3-4,7-10,22H,5-6H2,1-2H3/p+1 |
| InChI key | HVTCKKMWZDDWOY-UHFFFAOYSA-O |
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