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Biochem/physiol Actions
HS-1371 is a potent ATP-competitive RIP3 (RIPK3) kinase inhibitor (IC50 = 20.8 nM, [ATP] = 10 μM) that blocks RIP3 S227 autophosphorylation and selectively suppresses TNF/SMAC mimetic/Z-VAD-FMK agonist treatment-induced necroptosis induction in HT-29 cultures (by 44.4% at 1 μM, by 77.7% at 5 μM) in a RIP3- and MLKL-dependent manner.
Potent ATP-competitive RIP3 (RIPK3) kinase inhibitor that suppresses necroptosis in a RIP3- and MLKL-dependent manner.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | , White to very dark gray |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | CC(C=C1)=CC=C1OC2=CC=NC3=CC(C4=CN(C5CCNCC5)N=C4)=CC=C23 |
| InChI | 1S/C24H24N4O/c1-17-2-5-21(6-3-17)29-24-10-13-26-23-14-18(4-7-22(23)24)19-15-27-28(16-19)20-8-11-25-12-9-20/h2-7,10,13-16,20,25H,8-9,11-12H2,1H3 |
| InChI key | VPVLPCIBKVWFDT-UHFFFAOYSA-N |
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