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Biochem/physiol Actions
Potent dual BET/HDAC inhibitory (+)-JQ1 and CI994 hybrid with higher antiproliferation activty than (+)-JQ1 and/or CI994 in cancer cultures.
TW9 is a potent dual BET/HDAC inhibitory hybrid composed of the BET proteins BRD2/3/4/6 inhibitor (+)-JQ1 and the HDAC1/3 inhibitor CI994. TW9 has similar BRD4 affinity as (+)-JQ1 (BD1/BD2 Kd by ITC = 69/231 nM for TW9, 51/89 nM for JQ1; BD1/BD2/full-length IC50 by NonoBRET 720/74/640 nM for TW9, 231/39/104 nM for JQ1), while being more potent than CI994 against HDAC1 (IC50 = 290 nM/TW9, 960 nM/CI994). TW9 exhibits higher antiproliferation activty than (+)-JQ1 and/or CI994 in cancer cultures (0.05-2 µM; MIA PaCa-2, DAN-G, HPAC).
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(NC4=CC=C(C=C4)C(NC5=C(C=CC=C5)N)=O)=O)C6=NN=C(C)N26 |
| InChI | 1S/C32H28ClN7O2S/c1-17-18(2)43-32-28(17)29(20-8-12-22(33)13-9-20)36-26(30-39-38-19(3)40(30)32)16-27(41)35-23-14-10-21(11-15-23)31(42)37-25-7-5-4-6-24(25)34/h4-15,26H,16,34H2,1-3H3,(H,35,41)(H,37,42)/t26-/m0/s1 |
| InChI key | GGZYNJKDGRBRKG-SANMLTNESA-N |
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