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General description
Protein tyrosine phosphatase, receptor type B (PTPRB), also known as vascular endothelial-protein-tyrosine phosphatase (VE-PTP), might have a role in remodeling of blood vessels and in angiogenesis. The gene encoding it is localized on human chromosome 12q15. It is also important for endothelial cell migration. The protein also controls the phosphorylation state of the angiopoietin receptor, Tie-2. PTPRB may modulate sodium channels by influencing the tyrosine phosphorylation status.
Biochem/physiol Actions
Dephosphorylates tyrosine proteins.
Physical form
solution in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCL, 3 mM DTT, 16 mM glutathione and 20% glycerol
Other Notes
One unit of PTP-β will hydrolyze 1.0 nanomole of p-nitrophenyl phosphate per min at 30 °C.
| biological source | human |
| Quality Level | 200 |
| recombinant | expressed in E. coli K12 |
| assay | ≥90% |
| form | buffered aqueous glycerol solution |
| specific activity | ≥50,000 units/mg protein |
| mol wt | ~250 kDa |
| UniProt accession no. | P23467 |
| application(s) | cell analysis |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... PTPRB(5787) |
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¥ 2707.32
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¥ 4173.75
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¥ 1196.00
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¥ 1351.48
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¥ 70526.15
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¥ 165230.53
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¥ 25008.19
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¥ 21702.96
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