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General description
2′,3′-Didehydro-3′-deoxythymidine (d4T), a pyrimidine analogue is the inhibitor of reverse transcriptase.
Application
2′,3′-Didehydro-3′-deoxythymidine has been used in cell treatment. It has also been used as a drug in Caenorhabditis elegans to study drug induced mitochondrial toxicity. It has also been used in the preclinical evaluation of GS-9160.
Biochem/physiol Actions
2′,3′-Didehydro-3′-deoxythymidine is a nucleoside analog, which inhibits HIV replication in vitro. Stavudine has the ability to enter the cells by non-facilitated diffusion. It possesses inhibitory activity against moloney murine leukemia virus, friend murine leukemia virus and simian immunodeficiency virus.
| Quality Level | 200 |
| assay | ≥98% (TLC) |
| form | powder |
| storage temp. | −20°C |
| SMILES string | CC1=CN([C@@H]2O[C@H](CO)C=C2)C(=O)NC1=O |
| InChI | 1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1 |
| InChI key | XNKLLVCARDGLGL-JGVFFNPUSA-N |
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¥ 1302.89
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¥ 3109.49
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¥ 3442.25
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¥ 5725.45
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¥ 14407.09
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¥ 1564.00
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¥ 4020.77
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¥ 3404.94
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¥ 58184.19
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¥ 21144.84
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