Oxamflatin，5MG，O3139-5MG，Sigma

Application

Oxamflatin has been used as a histone deacetylase (HDAC) inhibitor:

• to study its effect on specificity protein 1 (Sp1) transcription and transactivation activity and CD1d mRNA expression in various tumor cells
• to study its inhibitory effect on long transcript- survival motor neuron gene 2 (SMN2) silencing mediated by DNA methylation
• to study its effect on somatic embryogenesis in Coffea arabica thorough a miniaturized and automated screening system
• to study its stand-alone effect on cytarabine-sensitive and resistant cells.

Biochem/physiol Actions

Histone deacetylase inhibitor; anti-cancer agent.
Oxamflatin is an aromatic sulfonamide derivative with a hydroxamic acid group. It stimulates the expression of the transcription factor, JunD, and fibronectin. In addition, oxamflatin also aids in the morphological reversion of various NIH3T3-derived transformed cell lines. It inhibits the proliferation of various mouse and human tumor cell lines in vitro.

Features and Benefits

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