- 商品介绍
- 规格参数
- 包装参数
Application
Nevirapine has been used as non-nucleoside reverse transcriptase inhibitor in in vitro porcine endogenous retrovirus replication, primary hepatocytes and bone marrow dendritic cells (BMDCs).
Biochem/physiol Actions
Nevirapine interacts with glycine 190 residue of human immuno deficiency virus (HIV-2) reverse transcriptase. It is an antiretroviral drug which increases bile synthesis and activates electron transport chain. Use of nevirapine leads to liver toxicity and is associated with Nevirapine hypersensitivity syndrome.
HIV-1 的 NNRTI（非核苷类逆转录酶抑制剂）
奈韦拉平是 HIV 逆转录酶（NNRTI）的变构非核苷抑制剂。奈韦拉平抑制野生型 RT 的 Ki 为 200 nM。
| assay | ≥98% (HPLC) |
| Quality Level | 100 |
| form | powder |
| color | white to tan |
| solubility | DMSO: ≥22 mg/mL |
| storage temp. | room temp |
| SMILES string | CC1=CC=NC2=C1NC(C(C=CC=N3)=C3N2C4CC4)=O |
| InChI | 1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20) |
| InChI key | NQDJXKOVJZTUJA-UHFFFAOYSA-N |
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| 重量(kg) |
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