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3-Ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene，10MG，E3145-10MG，Sigma

销售价： ¥ 2080.93 / 件

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订货号： 0BM1684

品牌型号： Sigma E3145-10MG

货期：询货期

最小订货量： 1件

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商品介绍
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产品介绍 Product Description

General description

3-Ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene (NOC12) is a donor of nitric oxide (NO). It has a long half-life of 327 minutes.

Application

3-Ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene has been used as nitric oxide (NO) donor to study its effects on the isolated trachea preparations from control and ovalbumin-sensitized guinea pigs in vitro. It has also been used as a NO-releasing substance to study its effects on the body contractions patterns of Tethya wilhelma.

Biochem/physiol Actions

3-Ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene (NOC12) liberates nitric oxide (NO) without the use of cofactors or enzymes and the formation of hazardous metabolites. A low dose of NOC12 protects astrocytes from reperfusion injury via a cyclic guanosine monophosphate (cGMP) signal. Higher dosages of NOC12 aggravates reperfusion damage through a cyclic guanosine monophosphate (cGMP)-independent mechanism.

技术参数 Specifications

Quality Level	200
assay	≥90%
storage temp.	−20°C
SMILES string	CCNCCN(CC)\[N+]([O-])=N\O
InChI	1S/C6H16N4O2/c1-3-7-5-6-9(4-2)10(12)8-11/h7,11H,3-6H2,1-2H3/b10-8-
InChI key	DPKCLDSTXVCYSN-NTMALXAHSA-N

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