- 商品介绍
- 规格参数
- 包装参数
General description
Anti-GRM2 Antibody detects endogenous levels of total GRM2 protein.
Metabotropic glutamate receptor 2 (MGLUR2/GRM2) with 872 amino acids, is encoded by the gene mapped to human chromosome 3. GRM2 belongs to the class c of G-protein-coupled receptor (GPCRs) family. It is expressed mainly in the central nervous system (CNS) of rat brain and widely expressed in human adult and fetal brain. GRM2 is characterized with an α-helical helix 8 (H8) domain.
Immunogen
The antiserum was produced against synthesized peptide derived from human GRM2.
Immunogen Range: 241-290
Biochem/physiol Actions
Metabotropic glutamate receptor (MGLUR2) is involved in the glutamatergic system in the brain. Overexpression of glutamate in brain areas such as the prefrontal cortex, hippocampus and amygdala leads to anxiety and schizophrenia, activation of MGLUR2 in these areas reduces the excitatory neurotransmission, therefore mGlu2 receptor might be considered as a potential target for the treatment of these diseases. GRM2 signaling inhibits adenylyl cyclase (AC) activity. GRM2 is required for the modulation of synaptic transmission.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 95 kDa |
| species reactivity | rat, human, mouse |
| concentration | ~1 mg/mL |
| technique(s) | ELISA: 1:1000,immunofluorescence: 1:100-1:500,immunohistochemistry: 1:50-1:100 |
| NCBI accession no. | Q14416 |
| UniProt accession no. | Q14416 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... GRM2(2912) |
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