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Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone，1MG，C1230-1MG，Sigma

销售价： ¥ 5341.40 / 件

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订货号： 0BM2891

品牌型号： Sigma C1230-1MG

货期：询货期

最小订货量： 1件

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商品介绍
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产品介绍 Product Description

Application

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) has been used as a caspase-8 inhibitor:

to study the activity of caspase-8 in porcine kidney cells
to study its effects on porcine parvovirus (PPV)-induced caspase-3 activity in steroidogenic luteal cells
to study its effects on retinal ganglion and astroglia in rat eyes

Biochem/physiol Actions

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) is an irreversible and cell-permeable caspase-8 inhibitor.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

技术参数 Specifications

biological source	synthetic (organic)
Quality Level	200
assay	≥90% (TLC)
form	powder
solubility	methanol: 10 mg/mL,DMSO: 20 mM, clear, colorless to light yellow
shipped in	dry ice
storage temp.	−20°C
SMILES string	CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(O)=O)C(=O)CF
InChI	1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9,15-16,18-19,23-24,34H,4,10-14H2,1-3H3,(H,30,41)(H,31,42)(H,32,40)(H,33,43)(H,36,37)(H,38,39)/t15-,16+,18-,19-,23-,24-/m0/s1
InChI key	CTXDBLYOEUERAT-VUVYEONESA-N

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