- 商品介绍
- 规格参数
- 包装参数
Application
Tyrphostin 51 has been used to study the inhibition of rat hepatic leptin 1.
Biochem/physiol Actions
EGFR tyrosine kinase inhibitor.
Tyrphostin 51 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Preparation Note
5 mg of Tyrphostin 51 is soluble in 0.1 ml of DMSO and yields a clear, orange to red solution.
| biological source | synthetic (organic) |
| Quality Level | 200 |
| assay | ≥98% |
| form | powder |
| potency | 0.8 μM IC50 |
| solubility | DMSO: soluble 5 mg of Tyrphostin 51 in 0.1 ml of solvent, clear, orange to red |
| storage temp. | 2-8°C |
| SMILES string | NC(\C(=C\c1cc(O)c(O)c(O)c1)C#N)=C(/C#N)C#N |
| InChI | 1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,18-20H,17H2/b8-1+ |
| InChI key | JKNOYWVMHPMBEL-UNXLUWIOSA-N |
| Gene Information | human ... CDK2(1017), EGFR(1956) |
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