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Biochem/physiol Actions
PD 173212 is a selective N-type (Cav2.2) voltage sensitive calcium channel (VSCC) blocker that potently inhibits VSCC-mediated calcium influx in IMR-32 human neuroblastoma cells (IC50 = 36 nM vs. 8%/Na+ channels & 10% K+ channels blockage at 1 μM, L-type Ca+2 channels IC50 >10 μM) with in vivo efficacy in a murine audiogenic zeisure model (80% tonic zeisure protection at 30 mg/kg i.v.).
Selective N-type voltage-gated calcium channel (VSCC) blocker with in vivo efficacy in a murine audiogenic seizure model.
| Quality Level | 100 |
| assay | ≥95% (HPLC) |
| form | (Powder, lyophilized powder, or film) |
| storage condition | desiccated |
| color | white to off-white |
| storage temp. | -10 to -25°C |
| SMILES string | O=C([C@@H](NC([C@@H](N(C)CC1=CC=C(C=C1)C(C)(C)C)CC(C)C)=O)CC2=CC=C(OCC3=CC=CC=C3)C=C2)NC(C)(C)C |
| InChI | 1S/C38H53N3O3/c1-27(2)23-34(41(9)25-29-15-19-31(20-16-29)37(3,4)5)36(43)39-33(35(42)40-38(6,7)8)24-28-17-21-32(22-18-28)44-26-30-13-11-10-12-14-30/h10-22,27,33-34H,23-26H2,1-9H3,(H,39,43)(H,40,42)/t33-,34-/m0/s1 |
| InChI key | GCDHMGROXQUFNR-HEVIKAOCSA-N |
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