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产品介绍
Product Description
Biochem/physiol Actions
Anti-proliferative; a potent anticancer agent.
Trabectedin is an alkylating drug that binds guanine residues in the minor groove of DNA, causing RNA polymerase II arrest, interfering with transcription and DNA repair pathways. It is anti-proliferative, a potent anticancer agent that has been approved to treat advanced soft tissue sarcoma and is being investigated for treatment of multiple other cancers.
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | CC(C1=C2OCO1)=C(OC(C)=O)C3=C2[C@H](CO4)N([C@@H](O)[C@H]5N(C)[C@@H]6C7=C(C5)C=C(C)C(OC)=C7O)C6[C@H]3SC[C@@]8(C4=O)NCCC9=C8C=C(OC)C(O)=C9 |
| InChI | 1S/C39H43N3O11S/c1-16-9-20-10-22-37(46)42-23-13-50-38(47)39(21-12-25(48-5)24(44)11-19(21)7-8-40-39)14-54-36(30(42)29(41(22)4)26(20)31(45)32(16)49-6)28-27(23)35-34(51-15-52-35)17(2)33(28)53-18(3)43/h9,11-12,22-23,29-30,36-37,40,44-46H,7-8,10,13-15H2,1-6H3/ |
| InChI key | PKVRCIRHQMSYJX-CXIMGACLSA-N |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
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