- 商品介绍
- 规格参数
- 包装参数
产品介绍
Product Description
Application
p-Fluorohexahydro-sila-difenidol hydrochloride (pFHHSid) has been used:
- as the M3/muscarinic acetylcholine receptor antagonist to study its involvement in carbachol induced Egr-1 biosynthesis using human neuroblastoma cells
- as M3 receptor antagonist to test its involvement on N,N-diethyl-m-toluamide (DEET)-induced angiogenesis in human umbilical venous endothelial cells (HUVEC)
- in a study to examine the role of aclidinium on human fibroblast to myofibroblast
Biochem/physiol Actions
High affinity M3 muscarinic acetylcholine receptor antagonist.
Features and Benefits
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | H2O: slightly soluble 1.5 mg/mL,45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >14 mg/mL,ethanol: soluble |
| SMILES string | Cl[H].O[Si](CCCN1CCCCC1)(C2CCCCC2)c3ccc(F)cc3 |
| InChI | 1S/C20H32FNOSi.ClH/c21-18-10-12-20(13-11-18)24(23,19-8-3-1-4-9-19)17-7-16-22-14-5-2-6-15-22;/h10-13,19,23H,1-9,14-17H2;1H |
| InChI key | JMTYYLMGSBSPPK-UHFFFAOYSA-N |
| Gene Information | human ... CHRM3(1131) |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
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