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Biochem/physiol Actions
GZ-11608 is a potent and selective inhibitor of vesicular monoamine transporter-2 (VMAT2) that diminished hERG interaction. GZ-11608 reduces behavioral effects of methamphetamine such as locomotor activity, self-administration, and methamphetamine seeking behavior. It does not exhibit abuse liability. GZ-11608 inhibits methamphetamine-induced dopamine release from isolated synaptic vesicles from brain dopaminergic neurons.
Potent and selective inhibitor of vesicular monoamine transporter-2 (VMAT2)
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | oil |
| color | colorless to brown |
| storage temp. | 2-8°C |
| SMILES string | N([C@H](Cc2ccccc2)C)CCCc1ccc(cc1)OC |
| InChI key | LKTLDVZCNLGHOG-INIZCTEOSA-N |
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¥ 1866.29
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¥ 9207.92
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¥ 3442.25
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¥ 3152.47
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¥ 5167.58
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¥ 6330.00
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¥ 1568.60
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¥ 2869.87
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¥ 1586.69
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¥ 3404.94
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