MRK-016，25MG，SML3088-25MG，Sigma

Biochem/physiol Actions

MRK-016 is an orally active, benzodiazepine site-targeting, alpha5-selective GABAA inverse agonist (Emax = -55%/α5, -16%/α1, -9%/α3, +6%/α2 of a EC20 GABA response using respective recombinant human αβ3γ2) with in vivo cognition-enhancing properties (0.3-3 mg/kg p.o. in rat Morris water maze test).
Orally active, benzodiazepine site-targeting, alpha5 (α5) subtype-selective GABAA inverse agonist with cognition-enhancing properties in vivo.