TH10785，25MG，SML3748-25MG，Sigma

Biochem/physiol Actions

8-oxoG DNA glycosylase OGG1 activator that induced β,δ-lyase activity for polynucleotide kinase phosphatase (PNKP1)-dependent base excision repair (BER).
TH10785 is an 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1) activator that interats with OGG1 via Phe319 and Gly42, causing increased OGG1 recruitment to cellular oxidative DNA damage sites (by 1.37-fold post 20 sec 1 µM treatment; U2OS). TH10785-activated OGG1 recognizes not only 8-oxoG, but also apurinic/apyrimidinic (AP, abasic) sites with a higher efficiency due to a newly induced β,δ-lyase enzymatic activity that generates base excision repair (BER) intermediates that require polynucleotide kinase phosphatase (PNKP1) instead of apurinic endonuclease 1 (APE1) for completing the repair.