- 商品介绍
- 规格参数
- 包装参数
Application
NSC232003 may be used to investigate its effect against various cancercell lines by targeting the SRA domain of Ubiquitin-like with PHD and RINGFinger domains 1 (UHRF1).
Biochem/physiol Actions
NSC232003 is a Ubiquitin-likewith PHD and RING Finger domains 1 (UHRF1) E3 ubiquitin ligase inhibitor thatdownregulates overall genomic DNA cytosine methylation (5 mC IC50 = 15 µM post72h treatment; U251 glioma cells) by disrupting UHRF1 interaction with DNAmethyltransferase DNMT1.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
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