Histone H3.1 human,100UG,H2292-100UG,Sigma

销售价: ¥ 1232.98 / 件
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订货号 0BN3731
品牌型号 Sigma H2292-100UG
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

Histone H3.1 is a histone H3 variant. It differs from H3.2 with residue 96 being a cysteine instead of serine. H3.1 is a replication-dependent histone and is a component of nucleosomes during the S-phase.


Application

Histone H3.1 human has been used in in vitro Schizosaccharomyces pombe Set7 histone methyltransferase assay for matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF) studies.


Biochem/physiol Actions

Histone H3.1 human (H3.1) undergoes a majority of post-translational modification especially acetylation and demethylation in lysine 14 and 9 respectively. During differentiation, the levels of H3.1 transcripts decrease as cell division slows down. The incorporation of H3.1 into chromatin is mediated by a chaperone, chromatin assembly factor (CAF-1). A transversion mutation in the H3.1 may be implicated in glioma.


Physical form

Supplied as 1 mg/mL in 20 mM NaPO4, pH 7.0, 0.3 M NaCl, 1 mM EDTA, and 1 mM DTT.


技术参数 Specifications
biological sourcehuman
Quality Level200
recombinantexpressed in E. coli
formliquid
concentration1 mg/mL
technique(s)MALDI-TOF: suitable
UniProt accession no.P68431
shipped inwet ice
storage temp.−20°C
Gene Informationhuman ... H3C1(8350)
长度(mm)
宽度(mm)
高度(mm)
重量(kg)
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