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Biochem/physiol Actions
BZ194 is a selective nicotinic acid-adenine dinucleotide phosphate (NAADP) antagonist that blocks NAADP-stimulated ryanodine binding to type 1 ryanodine receptor (RYR-1; IC50 ~10 uM against 1 uM NAADP). BZ194 inhibits Ca(2+) mobilization induced by NAADP (IC50 ~3 uM co-injected with 100 nM NAADP into Jurkat T cells), but not Ins(1,4,5)P3 or cyclic ADP-ribose (cADPR), and exhibits no inhibitory potency against capacitative Ca(2+) entry.
Selective nicotinic acid-adenine dinucleotide phosphate (NAADP) antagonist that blocks NAADP-stimulated ryanodine binding to RYR-1 and calcium mobilization.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | O=C(C[N+]1=CC(C(O)=O)=CC=C1)NCCCCCCCC.[Br-] |
| InChI | 1S/C16H24N2O3.BrH/c1-2-3-4-5-6-7-10-17-15(19)13-18-11-8-9-14(12-18)16(20)21;/h8-9,11-12H,2-7,10,13H2,1H3,(H-,17,19,20,21);1H |
| InChI key | LCFXDNPKEWPCGN-UHFFFAOYSA-N |
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