- 商品介绍
- 规格参数
- 包装参数
Application
Ani9 has been used to find out the inappropriate modulation of the membrane protein functions that are involved in the 198 ADGRG2- or Gq-mediated regulation of fluid reabsorption in the efferent ductules.
Biochem/physiol Actions
2-(4-chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide (Ani9), the most potent inhibitor, is the structural analog of Ani7. It may be considered as a novel candidate for drug therapy of cancer, hypertension, pain, diarrhea and asthma.
Ani9 is a potent and highly selective anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A) inhibitor that completely inhibited ANO1 chloride current with submicromolar potency. Ani9 does not affect the intracellular calcium signaling and CFTR chloride channel activity.
Ani9 is a potent and highly selective anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A) inhibitor.
| assay | ≥98% (HPLC) |
| Quality Level | 100 |
| form | powder |
| color | white to beige |
| solubility | DMSO: 25 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | CC1=C(OCC(NN=CC2=C(OC)C=CC=C2)=O)C=CC(Cl)=C1 |
| InChI key | KDALDZRKOBJXIE-UHFFFAOYSA-N |
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¥ 4164.19
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¥ 1451.54
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¥ 8293.41
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¥ 1724.25
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¥ 5167.58
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瓶顶过滤器-500ml容量,MF75TM系列，聚苯乙烯外壳，75mmSFCA滤膜，孔径0.2um,适合瓶颈尺寸45mm，12/箱，291-4520，Nalgene，Thermofisher，赛默飞世尔¥ 2856.42
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¥ 1156.91
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¥ 5426.00
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¥ 44224.19
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¥ 26846.31
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¥ 65710.50
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¥ 25551.73
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