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Biochem/physiol Actions
DIM-C-pPhOH is a NR4A1 (Nur77) antagonist that exhibit potent anticancer activity in pancreatic, colon, breast, kidney, and rhabdomyosarcoma cells. DIM-C-pPhOH decreases expression of PAX3-FOXO1A and β1-integrin proteins in Rh30 rhabdomyosarcoma and MDA-MB-231breast cancer cells. DIM-C-pPhOH inhibits migration of Rh30 and MDA-MB-231 cancer cells.
NR4A1 (Nur77) antagonist that exhibit potent anticancer activity
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | off-white to pink |
| solubility | DMSO: 2 mg/mL |
| storage temp. | −20°C |
| SMILES string | OC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1 |
| InChI | 1S/C23H18N2O/c26-16-11-9-15(10-12-16)23(19-13-24-21-7-3-1-5-17(19)21)20-14-25-22-8-4-2-6-18(20)22/h1-14,23-26H |
| InChI key | QCPDFNWJBQMXLI-UHFFFAOYSA-N |
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