- 商品介绍
- 规格参数
- 包装参数
General description
Calpain small subunit 1 (Capns1) is a small regulatory subunit associated with the μ-calpain (calpain 1) and m-calpain (calpain 2). The CAPNS1 gene is mapped to human chromosome 19q13.12.
Immunogen
purified calpain from human placenta.
Application
Monoclonal Anti-m/μ Calpain, Small Subunit antibody produced in mouse has been used in immunoprecipitation and immunoblotting.
Biochem/physiol Actions
Calpain small subunit 1 (Capns1) participates in the actin cytoskeleton rearrangement and cell migration events. It is crucial for embryonic development. Capns1 interacts with the Ras GTPase activating protein Src homology 3 domain (SH3) (RasGAP-SH3) domain to regulate cell migration and cell survival. It is essential for calpain activity. Capns1 is associated with the oncogenesis of many tumor types including hepatocellular, colorectal, ovarian, and breast cancer.
Physical form
Solution in 0.02 M sodium phosphate, pH 7.5, and 0.15 M sodium chloride containing 50% glycerol and 3 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Level | 200 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 28F3, monoclonal |
| form | buffered aqueous glycerol solution |
| mol wt | antigen 28-30 kDa |
| species reactivity | bovine, human |
| concentration | ~1 mg/mL |
| technique(s) | immunoprecipitation (IP): suitable,western blot: 1:5,000 using normal human fibroblasts or MDBK cells |
| isotype | IgG1 |
| UniProt accession no. | Q96L46 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... CAPNS1(826), CAPNS2(84290) |
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