- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
Lasmiditan (COL-144 and LY573144) is an orally active, potent and selective high-affinity serotonin receptor 5-HT1F agonist (5-HT1F/1E Ki = 2.21/594 nM; 5-HT1A/B/C Ki >1 μM; 5-HT2A/B/C Ki >2 μM; 5-HT6/7 Ki >3 μM). Lasmiditan induces mitochondrial biogenesis (MB) in human glomerular endothelial cells and mouse glomerular endothelial cells (100 nM for 72h). Unlike the triptans, Lasmiditan is void of vasoconstrictor activity toward isolated human coronary arteries (up to 100 μM) or in anaesthetized female beagle dogs in vivo (4.13-11.13 mg/kg i.v.)
Disclaimer
Hygroscopic, Store with desiccant
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| drug control | USDEA Schedule V |
| storage condition | desiccated |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| 长度(mm) | |
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| 重量(kg) |
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¥ 1866.29
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¥ 2068.25
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¥ 3109.49
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¥ 5887.85
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¥ 3290.05
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¥ 2883.61
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¥ 20380.83
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¥ 1196.00
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¥ 745.60
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NNALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/4 x 1/2 x 1/8，英寸，每箱数量50，50/箱，8000-0080，Thermofisher，赛默飞世尔
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