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RN-9893，25MG，SML1547-25MG，Sigma

销售价： ¥ 2943.97 / 件

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订货号： 0BN9656

品牌型号： Sigma SML1547-25MG

货期：询货期

最小订货量： 1件

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商品介绍
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产品介绍 Product Description

General description

RN-9893 is a small, orally bioavailable antagonist of TRPV4 (transient receptor potential subfamily V4. It is a tri-substituted benzamide compound.

Biochem/physiol Actions

RN-9893 is a potent and selective antagonist of the Transient Receptor Potential ion channel TRPV4.
RN-9893 is a potent and selective antagonist of the Transient Receptor Potential ion channel TRPV4. RN-9893 has IC₅₀ values of 420 nM, 660 nM, and 320 nM for human, rat and mouse TRPV4 receptors, respectively. RN-9893 shows excellent selectivity over related TRP receptors with no inhibition of TRPV1 at a concentration of 10 μM, an IC₅₀ >30 μM against TRPV3, an IC₅₀ of approximately 30 μM against TRPM8, and also good selectivity using 54 binding assays against common biological targets.

技术参数 Specifications

Quality Level	100
assay	≥98% (HPLC)
form	powder
color	white to beige
solubility	DMSO: 25 mg/mL, clear
storage temp.	2-8°C
SMILES string	O=C(NC1=CC=C(S(=O)(N2CCN(C(C)C)CC2)=O)C=C1)C3=CC=C(C(F)(F)F)C=C3[N+]([O-])=O
InChI	1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
InChI key	KORKKQLDGMHNKO-UHFFFAOYSA-N

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