- 商品介绍
- 规格参数
- 包装参数
Application
Ro 15-4513 has been used as a benzodiazepine (Bz) inverse agonist in rats and to test its binding with diazepam-sensitive (DS) receptors in in vitro radioligand binding studies.
Biochem/physiol Actions
Ro 15-4513 is benzodiazepine receptor partial inverse agonist. It elicits anxiogenic property and is an ethanol antagonist. It elicits a high affinity towards diazepam sensitive and insensitive sites in the cerebellar region. Ro 15-4513 possesses an imidazo ring and is an imidazobenzodiazepine.
Features and Benefits
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
| form | solid |
| Quality Level | 100 |
| color | tan |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL,H2O: insoluble,methanol: soluble |
| originator | Roche |
| SMILES string | CCOC(=O)c1ncn-2c1CN(C)C(=O)c3cc(ccc-23)N=[N+]=[N-] |
| InChI | 1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3 |
| InChI key | CFSOJZTUTOQNIA-UHFFFAOYSA-N |
| Gene Information | human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA5(2558), GABRA6(2559) rat ... Gabrg1(140674) |
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¥ 3109.49
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¥ 4039.86
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¥ 15214.65
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¥ 14407.09
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¥ 20380.83
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¥ 2666.57
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¥ 2277.64
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¥ 3404.94
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¥ 2099.27
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