- 商品介绍
- 规格参数
- 包装参数
Application
Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells.
Biochem/physiol Actions
Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor that can induce apoptosis in cancer cells, inhibit the growth of vascular smooth cells and block calcium release-dependent phosphorylations.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Preparation Note
Tyrphostin A9 is soluble in ethanol at 20 mg/ml, in DMSO at a concentration less than 25 mg/ml. It is insoluble in water.
| biological source | synthetic (organic) |
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | solid |
| color | yellow |
| mp | 139-140 °C |
| solubility | ethanol: 20 mg/mL,DMSO: <25 mg/mL,H2O: insoluble |
| SMILES string | CC(C)(C)c1cc(\C=C(\C#N)C#N)cc(c1O)C(C)(C)C |
| InChI | 1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3 |
| InChI key | MZOPWQKISXCCTP-UHFFFAOYSA-N |
| Gene Information | human ... EGFR(1956), ORAI1(84876), PDGFRA(5156), PDGFRB(5159) mouse ... Eef2k(13631), Prkaca(18747), Prkca(18750), Src(20779) |
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