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Biochem/physiol Actions
IDT307 (APP+) is a fluorescent analogue of the dopaminergic neurotoxin MPP+ monoamine transporter substrate that fluoresces after uptake into cells. IDT307 is a substrate for the dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT). IDT307 (APP+) was found to label catecholamine neuronal cell bodies with high selectivity in midbrain and was used to investigate SERT function in lymphocytes and platelets.
IDT307 (APP+) is a fluorescent analogue of the dopaminergic neurotoxin MPP+.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | , orange to dark orange-red |
| solubility | DMSO: 15 mg/mL, clear |
| storage temp. | −20°C |
| SMILES string | [I-].[n+]1(ccc(cc1)c2ccc(cc2)N(C)C)C |
| InChI | 1S/C14H17N2.HI/c1-15(2)14-6-4-12(5-7-14)13-8-10-16(3)11-9-13;/h4-11H,1-3H3;1H/q+1;/p-1 |
| InChI key | CAMWVBRDIKKGII-UHFFFAOYSA-M |
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