- 商品介绍
- 规格参数
- 包装参数
Application
LP44 has been used as a 5-hydroxytryptamine (serotonin) receptor 7 (5-HT7) agonist to study its effects on mitochondria-mediated leucine-rich repeat and pyrin domain containing 3 (NLRP3) inflammasome activation.
Biochem/physiol Actions
LP44 is a high affinity 5-HT7 receptor agonist.
LP44 is a high affinity 5-HT7 receptor agonist. Ki = 0.22 nM. LP44 displays selectivity over 5-HT1A and 5-HT2A receptors (200- and >1000-fold, respectively). LP44 induces relaxation of substance P-stimulated guinea pig ileum (EC50 = 2.56 μM).
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | solid |
| solubility | DMSO: >10 mg/mL,H2O: ≥2 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | Cl.CSc1ccccc1N2CCN(CCCCCC(=O)NC3CCCc4ccccc34)CC2 |
| InChI | 1S/C27H37N3OS.ClH/c1-32-26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24;/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31);1H |
| InChI key | DWGKCWWWKHCVDH-UHFFFAOYSA-N |
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¥ 2013.69
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¥ 2068.25
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¥ 8135.09
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¥ 4968.78
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