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Biochem/physiol Actions
BEPP is a double-strand RNA-dependent protein kinase (PKR) activator. The double-strand RNA (dsRNA)-dependent protein kinase is a ubiquitously expressed serine threonine kinase, inducible by interferon γ. PRK is involved in several curtail cellular regulations including phosphorylation of eIF2α (which leads to inhibition of protein synthesis and eliciting antivirus and antitumor activities), modulating activities of eIF2α, NF-κB, ATF-3, and p53. BEPP also inhibits the growth of a human lung cancer cell line overexpressing PKR.
BEPP is a double-strand RNA-dependent protein kinase (PKR) activator.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to off-white |
| solubility | DMSO: >10 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | Cl.OC(COc1ccccc1)CN2C(=N)N(Cc3ccccc3)c4ccccc24 |
| InChI | 1S/C23H23N3O2.ClH/c24-23-25(15-18-9-3-1-4-10-18)21-13-7-8-14-22(21)26(23)16-19(27)17-28-20-11-5-2-6-12-20;/h1-14,19,24,27H,15-17H2;1H |
| InChI key | KDMXJFUGIDGZQL-UHFFFAOYSA-N |
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¥ 2622.09
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¥ 1259.40
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¥ 8520.40
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