- 商品介绍
- 规格参数
- 包装参数
Application
AU-15330 may be usedin molecular biology and cancer research applications.
Biochem/physiol Actions
AU-15330 is a highly-selective proteolysis-targeting chimera (PROTAC) degrader of both SWItch/SucroseNon-Fermentable (SWI/SNF) adenosine triphosphatase (ATPase) subunits— SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 & 4 SMARCA2 (BRM)and SMARCA4 (BRG1) SWI/SNF ATPases. It potently inhibits tumor growth in xenograft models of prostate cancer. AU-15330 comprises a bait moiety that binds the bromodomain in SMARCA2 and SMARCA4 and a ligand moiety for the von Hippel–Lindau (VHL) ubiquitin ligase. It synergized with the androgen receptor antagonist enzalutamide.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N(CC3)CCN3CC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C6=C(N=CS6)C)C=C5)C)=O)=O)=O |
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¥ 2707.32
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¥ 1683.78
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¥ 5725.45
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¥ 2151.46
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¥ 1749.15
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¥ 44224.19
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¥ 8072.66
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¥ 29754.56
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