- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
Inhibitor of the Myeloid Src-Family Kinase Fgr
TL02-59 is a potent inhibitor of Fgr kinase, a Src-family kinase expressed in myeloid cells and associated with acute myelogenous leukemia (AML). It exhibited an IC50 value of 0.03 nM for Fgr, 0.10 nM for related Src-family kinase Lyn, with >1000-fold less potency for all other kinases tested. TL02-59 given orally in a mouse xenograft model of AML was able to eliminate spleen and peripheral blood leukemic cells and significantly reduce bone marrow engraftment.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | −20°C |
| SMILES string | O=C(NC1=CC(C(F)(F)F)=C(CN2CCN(CC)CC2)C=C1)C3=CC(OC4=C(C=C(C(OC)=C5)OC)C5=NC=N4)=C(C)C=C3 |
| InChI | 1S/C32H34F3N5O4/c1-5-39-10-12-40(13-11-39)18-22-8-9-23(15-25(22)32(33,34)35)38-30(41)21-7-6-20(2)27(14-21)44-31-24-16-28(42-3)29(43-4)17-26(24)36-19-37-31/h6-9,14-17,19H,5,10-13,18H2,1-4H3,(H,38,41) |
| InChI key | AMHWQBGAKJESFB-UHFFFAOYSA-N |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
¥ 1573.49
-
询价
-
询价
-
¥ 1302.89
-
询价
-
询价
-
询价
-
询价
-
询价
-
询价
-
询价
-
¥ 1509.00
-
¥ 1156.91
-
¥ 2099.27
-
¥ 2288.54
-
询价
-
¥ 44224.19
-
¥ 14985.93
-
询价
-
¥ 39793.68
微信小程序
7X24小时在线咨询