- 商品介绍
- 规格参数
- 包装参数
Application
CBR-5884 has been used as a 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor to explore the role of PHGDH in Müller cells from different retinal regions and also used in trypan blue exclusion assay to determine the number of viable MYCN cells.
Biochem/physiol Actions
CBR-5884 is a cell penetrant, potent and selective noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) that inhibits proliferation of melanoma and breast cancer lines. CBR-5884 inhibits de novo serine synthesis in in cancer cells.
CBR-5884 is a cell penetrant, potent and selective noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH).
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | paste |
| color | white to beige |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | CC1=C(C(OCC)=O)SC(NC(C2=CC=CO2)=O)=C1SC#N |
| InChI | 1S/C14H12N2O4S2/c1-3-19-14(18)11-8(2)10(21-7-15)13(22-11)16-12(17)9-5-4-6-20-9/h4-6H,3H2,1-2H3,(H,16,17) |
| InChI key | QBVIRPJBDIZKBC-UHFFFAOYSA-N |
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¥ 1148.92
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¥ 1596.77
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¥ 1779.22
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¥ 8135.09
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¥ 4390.38
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¥ 4404.38
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¥ 2151.46
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¥ 2842.54
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¥ 1509.00
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