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- 规格参数
- 包装参数
Biochem/physiol Actions
CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1.
CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC50 for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
| Quality Segment | 100 |
| assay | ≥97% (chiral, HPLC) |
| form | solid |
| solubility | DMSO: >10 mg/mL,H2O: <2 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | ClC1=CC=C(NC2=C3CCCC[C@@H]2C(N)=O)C3=C1 |
| InChI | 1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1 |
| InChI key | ABIVOOWWGYJNLV-JTQLQIEISA-N |
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