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Application
MI-181 may be used to evaluate its anti-cancer properties in various cancer cell lines, demonstrating activity against a broad spectrum of cancers, including melanomas harboring specific mutations like BRAFV600E.
Biochem/physiol Actions
MI-181, a potent small synthetic microtubule-targeting anticancer agent, acts as a mitotic inhibitor, arresting cancer cells during the M-phase of the cell cycle. It inhibits microtubule polymerization, arrests cells in mitosis, activates the spindle assembly checkpoint, and/or triggers apoptotic cell death.
MI-181 serves as a microtubule destabilization agent that targets β-tubulin near the colchicine-binding site and causes microtubule depolymerization, activates the spindle assembly checkpoint (SAC), arrests cells in mitosis (76.6%, IC50 = 23.6 nM post 20h treatment of HeLa), and induces apoptotic death in cancer cultures (HeLa/M233/NCI-H460/U2OS/CCRF-CEM viability IC50 post 72h = 30//30/36/60/100 nM). MI-181 is also a potent modulator of cilia length and biogenesis (length post 24h with/without 100 nM MI-181 = 6.09/3.52 μm (serum withdrawal) or 4.75/2.97 μm (with serum); hTERT RPE-1 cells), while microtubule destabilizers (10 μM colchicine, 116 nM nocodazole) and stabilizer (100 nM paclitaxel) causes decreased cilia length.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
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¥ 1148.92
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¥ 2528.88
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¥ 4039.86
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¥ 3275.78
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¥ 1156.91
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¥ 1196.14
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