EVP4593,5MG,SML0579-5MG,Sigma

销售价: ¥ 1607.37 / 件
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订货号 0BQ5523
品牌型号 Sigma SML0579-5MG
货期 询货期
最小订货量 1件
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产品介绍 Product Description

Biochem/physiol Actions

EVP4593 is a high affinity partial antagonist of NF-KB pathway activation acting by inhibiting store-operated calcium (Ca2+) entry (SOC).
EVP4593 is a high affinity partial antagonist of NF-KB pathway activation acting by inhibiting store-operated calcium (Ca2+) entry (SOC). It appears that EVP4593 targets heteromeric channels containing TRPC1 as one of the subunits in HD neurons. EVP4593 exhibits neuroprotective effects from glutamate toxicity in nanomolar concentrations.


Features and Benefits

This compound is featured on the Calcium Channels, Cytokine Receptors (Interleukin-1 Receptor/TIR Family) and Cytokine Receptors (Tumor Necrosis Receptor Family) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


Other Notes

Air sensitive


技术参数 Specifications
Quality Segment100
assay≥98% (HPLC)
formpowder
storage conditiondesiccated
color white to beige
solubilityDMSO: 15 mg/mL, clear
storage temp.2-8°C
SMILES stringNC1=CC(C(NCCC2=CC=C(OC3=CC=CC=C3)C=C2)=NC=N4)=C4C=C1
InChI1S/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26)
InChI keyIBAKVEUZKHOWNG-UHFFFAOYSA-N
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