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Biochem/physiol Actions
ASC-J9 (dimethylcurcumin) is an androgen receptor (AR)-selective degradation promoter that disrupts the interaction between AR and its coregulators. ASC-J9 induces AR degration in cultures (5 µM, LNCaP) and shows in vivo therapeutic efficacy (50 mg/kg i.p. qod) in murine bladder cancer (TCC-SUP and UMUC3 xenografts) and a spinal and bulbar muscular atrophy disease model (AR-polyQ transgenic SBMA mice).
Androgen receptor (AR)-selective degradation promoter in cultures and in vivo.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | , White to light orange |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | −20°C |
| SMILES string | OC(/C=C/C1=CC(OC)=C(C=C1)OC)=C\C(/C=C/C2=CC(OC)=C(C=C2)OC)=O |
| InChI | 1S/C23H24O6/c1-26-20-11-7-16(13-22(20)28-3)5-9-18(24)15-19(25)10-6-17-8-12-21(27-2)23(14-17)29-4/h5-15,24H,1-4H3/b9-5+,10-6+,18-15- |
| InChI key | ZMGUKFHHNQMKJI-CIOHCNBKSA-N |
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