Zatebradine hydrochloride，50MG，Z0127-50MG，Sigma

Application

Zatebradine hydrochloride has been used:

• as an I_f blocker to study its effects on cardiomyocyte clusters (CMCs)
• as a hyperpolarization-activated and cyclic nucleotide-gated (HCN) channel inhibitor to study its effects on viability of degenerating rod or cone photoreceptors in mice
• as a bradycardiac agent to study its effects on tachycardia and elevated temperature in fish

Biochem/physiol Actions

Zatebradine is a bradycardiac agent.
HCN channel blocker: blocker of neuronal I_h, related cardiac I_f channels and ATP-sensitive K_ir channels.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.