(Z-LL)2 Ketone，1MG，SML1442-1MG，Sigma

Biochem/physiol Actions

(Z-LL)2 Ketone serves as an inverse γ-secretase modulator (iGSM) by changing processivity of γ-secretase cleavage.
(Z-LL)2 Ketone is a selective inhibitor of signal peptide peptidase (SPP) that inhibits processing of the p-Prl signal peptide (IC₅₀ = ~ 50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes.
(Z-LL)2 Ketone is a selective inhibitor of signal peptide peptidase (SPP).