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ALX 5407 hydrochloride，5MG，SML0897-5MG，Sigma

销售价： ¥ 1323.95 / 件

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订货号： 0BQ7061

品牌型号： Sigma SML0897-5MG

货期：询货期

最小订货量： 1件

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商品介绍
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包装参数

产品介绍 Product Description

Application

ALX 5407 hydrochloride has been used as a glycine transporter (GlyT1) inhibitor to test its effect on inhibitory postsynaptic current and N-methyl-D-aspartate receptor (NMDA)-mediated excitatory postsynaptic currents (EPSCs). It has also been used as a GlyT1 inhibitor to treat developmentally diminished NMDA receptor (Grin1D481N) mice to test its effect on the glycine site function.

Biochem/physiol Actions

ALX 5407 is a selective, irreversible GlyT-1 glycine transporter inhibitor.
ALX-5407 hydrochloride (NFPS hydrochloride) is a selective irreversible inhibitor of the glycine transporter GlyT1 with IC₅₀ values of 3 nM for GlyT1 compared to 100 μM for GlyT2. ALX-5407 hydrochloride showed no activity at the inhibitory glycine receptor or glycine site of the NMDA receptor (IC₅₀ > 100 mM).

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

技术参数 Specifications

Quality Segment	100
assay	≥98% (HPLC)
form	powder
storage condition	desiccated
color	white to beige
solubility	DMSO: 5 mg/mL, clear (warmed)
storage temp.	2-8°C
SMILES string	Cl.CN(CC[C@@H](Oc1ccc(cc1)-c2ccccc2)c3ccc(F)cc3)CC(O)=O
InChI	1S/C24H24FNO3.ClH/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18;/h2-14,23H,15-17H2,1H3,(H,27,28);1H/t23-;/m1./s1
InChI key	RPDGSZCYSJWQEE-GNAFDRTKSA-N

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