- 商品介绍
- 规格参数
- 包装参数
Application
Deshydroxy LY-411575 has been used in dibenzazepine (DBZ) treatment and chemical treatment.
Biochem/physiol Actions
LY411575 prevents SPP (signal peptide peptidase) dependent cleavage of HCV (hepatitis C virus) core protein.
Deshydroxy LY-411575 is a cell-permeable γ-secretase inhibitor and inhibtor of Notch processing.
Deshydroxy LY-411575 is a cell-permeable γ-secretase inhibitor and inhibtor of Notch processing. Deshydroxy LY-411575 significantly lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model and potently blocks Notch processing, with an IC50 of 1.7 nM in SupT1 cells.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| optical activity | [α]/D -128.0 to -154.0°-0.25 in methanol |
| color | white to beige |
| solubility | DMSO: 15 mg/mL, clear |
| storage temp. | −20°C |
| SMILES string | Fc1cc(cc(c1)CC(=O)N[C@@H](C)C(=O)N[C@H]2c3c(cccc3)c4c(cccc4)N(C2=O)C)F |
| InChI | 1S/C26H23F2N3O3/c1-15(29-23(32)13-16-11-17(27)14-18(28)12-16)25(33)30-24-21-9-4-3-7-19(21)20-8-5-6-10-22(20)31(2)26(24)34/h3-12,14-15,24H,13H2,1-2H3,(H,29,32)(H,30,33)/t15-,24-/m0/s1 |
| InChI key | QSHGISMANBKLQL-OWJWWREXSA-N |
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| 重量(kg) |
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