- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
LLY-507 is a potent and selective inhibitor of SMYD2 protein lysine methyltransferase (PKMT) with an in vitro IC50 <15 nM and >100-fold selectivity over other methyltransferases and other non-epigenetic targets. LY-507 has been shown to inhibit p53K370 monomethylation in cells with an IC50 ~600 nM. For full characterization details, please visit the LLY-507 probe summary on the Structural Genomics Consortium (SGC) website.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
LLY-507 is a potent and selective inhibitor of SMYD2 protein lysine methyltransferase (PKMT).
Features and Benefits
LLY-507 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Other Notes
LLY-507 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the LLY-507 probe summary on the Chemical Probes Portal website.
| Quality Segment | 100 |
| assay | ≥97% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 5 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
| SMILES string | CC(C1=C2C=CC=C1)=CN2CCN(CC3)CCN3C4=CC=CC=C4C5=CC(C#N)=CC(C(NCCCN6CCCC6)=O)=C5 |
| InChI | 1S/C36H42N6O/c1-28-27-42(34-11-4-2-9-32(28)34)22-19-40-17-20-41(21-18-40)35-12-5-3-10-33(35)30-23-29(26-37)24-31(25-30)36(43)38-13-8-16-39-14-6-7-15-39/h2-5,9-12,23-25,27H,6-8,13-22H2,1H3,(H,38,43) |
| InChI key | PNYRDVBFYVDJJI-UHFFFAOYSA-N |
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¥ 1779.22
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¥ 3442.25
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¥ 8520.40
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¥ 2151.46
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¥ 2617.87
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¥ 1564.00
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¥ 5061.38
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¥ 2869.87
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