- 商品介绍
- 规格参数
- 包装参数
产品介绍
Product Description
Application
4-Methylpyrazole hydrochloride has been used:
- as a cytochrome P450 2E1 inhibitor
- as cytochrome P450 2E1 and alcohol dehydrogenase inhibitor in 1C11 neural progenitor cells
- to inhibit ethanol oxidation in VL-17A cells expressing alcohol dehydrogenase and HepG2 cells
Useful as an antidote in methanol and ethylene glycol poisoning.
Biochem/physiol Actions
醇脱氢酶抑制剂
4-Methylpyrazole (4MP) inhibits ethanol oxidation in liver microsomes. It also blocks the c-Jun N-terminal kinase (JNK) activation in in vitro liver injury models.
技术参数
Specifications
| biological source | synthetic (organic) |
| Quality Segment | 200 |
| assay | ≥95% |
| form | powder |
| mp | 157-159 °C |
| solubility | methanol: 100 mg/mL, clear, colorless to yellow |
| storage temp. | 2-8°C |
| SMILES string | Cl.Cc1cn[nH]c1 |
| InChI | 1S/C4H6N2.ClH/c1-4-2-5-6-3-4;/h2-3H,1H3,(H,5,6);1H |
| InChI key | PUCXJHNDMYZOHG-UHFFFAOYSA-N |
| Gene Information | human ... ADH1A(124), ADH1B(125), ADH1C(126) |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
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