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Biochem/physiol Actions
3-aminopyridine carboxaldehyde thiosemicarbazone (3-AP) has a IC50 value of 0.3μM. It exhibits anti-proliferative activity in preclinical models of cancer, such as lung cancer. It also has an ability to increase the cytotoxicity, intracellular uptake and DNA incorporation of gemcitabine in vitro.
3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) is a ribonucleotide reductase inhibitor and iron chelator with anti-tumor activity.
3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) is a ribonucleotide reductase inhibitor and iron chelator with anti-tumor activity.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to light brown |
| solubility | DMSO: 10 meq/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | S=C(N\N=C\c1ncccc1N)N |
| InChI | 1S/C7H9N5S/c8-5-2-1-3-10-6(5)4-11-12-7(9)13/h1-4H,8H2,(H3,9,12,13)/b11-4+ |
| InChI key | XMYKNCNAZKMVQN-NYYWCZLTSA-N |
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¥ 1573.49
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¥ 2013.69
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¥ 3152.47
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¥ 4897.21
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¥ 2268.97
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¥ 2617.87
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¥ 1783.21
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¥ 5804.96
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