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Biochem/physiol Actions
Fenobam is a potent, selective, noncompetitive glutamate mGluR5 receptor antagonist. Fenobam displays inverse agonist properties; blocks mGluR5 constitutive activity in vitro (IC50 = 87 nM, slightly weaker than MPEP). Fenobam acts at an allosteric modulatory site shared with MPEP and binds the mGlu5 receptor with Kd values of 54 and 31 nM for rat and human receptors, respectively. Fenobam belongs to a structurally different class than MPEP; devoid of GABAergic activity and thus typical benzodiazepine-like side effects; displays anxiolytic activity.
Potent, selective, noncompetitive metabotropic glutamate receptor antagonist (mGluR5). Displays anxiolytic activity.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | solid |
| color | white |
| solubility | DMSO: >20 mg/mL |
| web metadata keyword.default | ACS grade Fenobam for laboratory use,Fenobam 1g non-GABAergic compound,Fenobam 500mg research chemical,Fenobam 57653-26-6,Fenobam antagonist properties and applications,Fenobam for academic research,Fenobam for in vitro studies,Fenobam for pharmacological research,Fenobam noncompetitive mGluR5 antagonist,Fenobam selectivity profile for mGluR5,N-(3-Chlorophenyl)-N′-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea CAS 57653-26-6,N-(3-Chlorophenyl)-N′-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea chemical,high purity Fenobam for neuroscience research,mGluR5 antagonist Fenobam |
| originator | Johnson & Johnson |
| storage temp. | 2-8°C |
| SMILES string | CN1CC(=O)N=C1NC(=O)Nc2cccc(Cl)c2 |
| InChI | 1S/C11H11ClN4O2/c1-16-6-9(17)14-10(16)15-11(18)13-8-4-2-3-7(12)5-8/h2-5H,6H2,1H3,(H2,13,14,15,17,18) |
| InChI key | DWPQODZAOSWNHB-UHFFFAOYSA-N |
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